Item Type | Name |
Concept
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Immunoglobulin Heavy Chains
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Concept
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Immunoglobulin gamma-Chains
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Concept
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Immunoglobulin J-Chains
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Concept
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Gene Rearrangement, B-Lymphocyte
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Concept
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Immunoglobulin alpha-Chains
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Concept
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Immunoglobulin lambda-Chains
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Concept
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Immunoglobulin mu-Chains
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Concept
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Gene Rearrangement, T-Lymphocyte
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Concept
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Reverse Transcriptase Polymerase Chain Reaction
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Concept
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Gene Rearrangement, B-Lymphocyte, Heavy Chain
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Concept
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Gene Rearrangement, B-Lymphocyte, Light Chain
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Concept
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Polymerase Chain Reaction
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Concept
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Immunoglobulin kappa-Chains
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Concept
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Immunoglobulin Light Chains
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Concept
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Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
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Academic Article
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PU.1 is a component of a multiprotein complex which binds an essential site in the murine immunoglobulin lambda 2-4 enhancer.
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Academic Article
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Influence of CpG methylation and target spacing on V(D)J recombination in a transgenic substrate.
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Academic Article
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N region diversity of a transgenic substrate in fetal and adult lymphoid cells.
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Academic Article
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Somatic hypermutation of a lambda 2 transgene under the control of the lambda enhancer or the heavy chain intron enhancer.
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Academic Article
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Identification and characterization of the murine Rag1 promoter.
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Academic Article
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Gamma 2b provides only some of the signals normally given via mu in B cell development.
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Academic Article
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Somatic hypermutation of an artificial test substrate within an Ig kappa transgene.
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Academic Article
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B lymphocytes of xeroderma pigmentosum or Cockayne syndrome patients with inherited defects in nucleotide excision repair are fully capable of somatic hypermutation of immunoglobulin genes.
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Academic Article
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The inactivation of the XP-C gene does not affect somatic hypermutation or class switch recombination of immunoglobulin genes.
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Academic Article
|
The composition of coding joints formed in V(D)J recombination is strongly affected by the nucleotide sequence of the coding ends and their relationship to the recombination signal sequences.
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Academic Article
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Mef2 proteins, required for muscle differentiation, bind an essential site in the Ig lambda enhancer.
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Academic Article
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Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes.
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Academic Article
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A hypermutable insert in an immunoglobulin transgene contains hotspots of somatic mutation and sequences predicting highly stable structures in the RNA transcript.
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Academic Article
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Hypomethylation is necessary but not sufficient for V(D)J recombination within a transgenic substrate.
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Academic Article
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Insertion of phosphoglycerine kinase (PGK)-neo 5' of Jlambda1 dramatically enhances VJlambda1 rearrangement.
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Academic Article
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Signal joint formation is inhibited in murine scid preB cells and fibroblasts in substrates with homopolymeric coding ends.
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Academic Article
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Analysis of a T cell receptor gene as a target of the somatic hypermutation mechanism.
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Academic Article
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A point mutation in the constant region of Ig lambda1 prevents normal B cell development due to defective BCR signaling.
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Academic Article
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Two conserved essential motifs of the murine immunoglobulin lambda enhancers bind B-cell-specific factors.
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Academic Article
|
Mutation pattern of immunoglobulin transgenes is compatible with a model of somatic hypermutation in which targeting of the mutator is linked to the direction of DNA replication.
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Academic Article
|
Identification and localization of an enhancer for the human lambda L chain Ig gene complex.
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Academic Article
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Delay of early B-lymphocyte development by gamma 2b immunoglobulin transgene: effect on differentiation-specific molecules.
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Academic Article
|
Scarcity of lambda 1 B cells in mice with a single point mutation in C lambda 1 is due to a low BCR signal caused by misfolded lambda 1 light chain.
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Academic Article
|
The published data.
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Academic Article
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Factors affecting the rearrangement efficiency of an Ig test gene.
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Academic Article
|
A novel enhancer in the immunoglobulin lambda locus is duplicated and functionally independent of NF kappa B.
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Academic Article
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Differential splicing of thymosin beta 4 mRNA.
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Academic Article
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Transgenic mice with mu and kappa genes encoding antiphosphorylcholine antibodies.
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Academic Article
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Brca1 in immunoglobulin gene conversion and somatic hypermutation.
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Academic Article
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Somatic hypermutation of an immunoglobulin transgene in kappa transgenic mice.
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Academic Article
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The switch region associated with immunoglobulin C mu genes is DNase I hypersensitive in T lymphocytes.
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Academic Article
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Cloning of a gamma 2b gene encoding anti-Pseudomonas aeruginosa H chains and its introduction into the germ line of mice.
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Academic Article
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Alteration of the B cell surface phenotype, immune response to phosphocholine and the B cell repertoire in M167 mu plus kappa transgenic mice.
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Academic Article
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Elevated PC responsive B cells and anti-PC antibody production in transgenic mice harboring anti-PC immunoglobulin genes.
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Academic Article
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Misalignment of V and J gene segments resulting in a nonfunctional immunoglobulin gene.
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Academic Article
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Comparison of different rearranged immunoglobulin kappa genes of a myeloma by electronmicroscopy and restriction mapping of cloned DNA: implications for "allelic exclusion".
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Academic Article
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Allelic exclusion and control of endogenous immunoglobulin gene rearrangement in kappa transgenic mice.
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Academic Article
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Structural alterations in J regions of mouse immunoglobulin lambda genes are associated with differential gene expression.
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Academic Article
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Ig lambda-producing B cells do not show feedback inhibition of gene rearrangement.
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Academic Article
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Analysis of immunoglobulin genes: DNA/RNA hybridization with immunoglobulin kappa-chain mRNA and isolation and translation of hybridized RNA.
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Academic Article
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Direct demonstration of immunoglobulin kappa chain RNA in thymus T cells by in situ hybridization.
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Academic Article
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Sequences related to immunoglobulin kappa chain messenger RNA in T cells.
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Academic Article
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Immunoglobulin gene 'remnant' DNA--implications for antibody gene recombination.
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Academic Article
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Somatic mutation of immunoglobulin light-chain variable-region genes.
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Academic Article
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Association of two different repetitive DNA elements near immunoglobulin light chain genes.
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Academic Article
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Gamma 2b transgenic mice as a model for the role of immunoglobulins in B cell development.
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Academic Article
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lambda 5, but not mu, is required for B cell maturation in a unique gamma 2b transgenic mouse line.
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Academic Article
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Expression, allelic exclusion and somatic mutation of mouse immunoglobulin kappa genes.
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Academic Article
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Transgenic mice with immunoglobulin genes.
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Academic Article
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The order and orientation of mouse lambda-genes explain lambda-rearrangement patterns.
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Academic Article
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Fusion of a scid pre-B cells with a wild type (myeloma) B cell results in correct rearrangement of a V(D)J recombination substrate.
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Academic Article
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Antibody-carrying cells in the immune response 1. Identification of "rosette"-forming cells by light microscopy.
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Academic Article
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Immunoglobulin mu- and gamma-ribonucleic acid sequences in thymocytes and splenocytes from normal and hyperimmune mice.
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Academic Article
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Heterogeneity of the 3' portion of sequences related to immunoglobulin kappa-chain mRNA.
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Academic Article
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Myeloma with multiple rearranged immunoglobulin kappa genes: only one kappa gene codes for kappa chains.
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Academic Article
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Expression of a microinjected immunoglobulin gene in the spleen of transgenic mice.
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Academic Article
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RNA sequences homologous to the 3' portion of immunoglobulin alpha-chain mRNA in thymus-derived lymphocytes.
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Academic Article
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Sequences of immunoglobulin lambda 1 genes in a lambda 1 defective mouse strain.
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Academic Article
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Evolution of mouse immunoglobulin lambda genes.
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Academic Article
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Expression of lambda and kappa genes can occur in all B cells and is initiated around the same pre-B-cell developmental stage.
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Academic Article
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Immunoglobulin gamma 2b transgenes inhibit heavy chain gene rearrangement, but cannot promote B cell development.
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Academic Article
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Rearranged and germline immunoglobulin kappa genes: different states of DNase I sensitivity of constant kappa genes in immunocompetent and nonimmune cells.
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Academic Article
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Physical linkage of the constant region genes for immunoglobulins lambda I and lambda III.
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Academic Article
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Crossing the SJL lambda locus into kappa-knockout mice reveals a dysfunction of the lambda 1-containing immunoglobulin receptor in B cell differentiation.
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Academic Article
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Different mismatch repair deficiencies all have the same effects on somatic hypermutation: intact primary mechanism accompanied by secondary modifications.
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Academic Article
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The C(H)1 and transmembrane domains of mu in the context of a gamma2b transgene do not suffice to promote B cell maturation.
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Academic Article
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The 3' Igkappa enhancer contains RNA polymerase II promoters: implications for endogenous and transgenic kappa gene expression.
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Academic Article
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The transcription factor Spi-B is not required for somatic hypermutation.
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Academic Article
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Precursors of both conventional and Ly-1 B cells can escape feedback inhibition of Ig gene rearrangement.
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Academic Article
|
The very 5' end and the constant region of Ig genes are spared from somatic mutation because AID does not access these regions.
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Academic Article
|
Inhibition of immunoglobulin gene rearrangement by the expression of a lambda 2 transgene.
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Academic Article
|
High-frequency deletional rearrangement of immunoglobulin kappa gene segments introduced into a pre-B-cell line.
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Academic Article
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Feedback inhibition of immunoglobulin gene rearrangement by membrane mu, but not by secreted mu heavy chains.
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Academic Article
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Pre-B cells in kappa-transgenic mice.
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Academic Article
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High expression of cloned immunoglobulin kappa gene in transgenic mice is restricted to B lymphocytes.
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Academic Article
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Mapping of immunoglobulin variable region genes: relationship to the 'deletion' model of immunoglobulin gene rearrangement.
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Academic Article
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Changes in RNA polymerase II progression influence somatic hypermutation of Ig-related genes by AID.
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Academic Article
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Why does somatic hypermutation by AID require transcription of its target genes?
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Academic Article
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The central vessel of the renal countercurrent bundles of two marine elasmobranchs--dogfish (Scyliorhinus caniculus) and skate (Raja erinacea)--as revealed by light and electron microscopy with computer-assisted reconstruction.
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Grant
|
EXPRESSION OF IMMUNOGLOBULIN GENES IN TRANSGENIC MICE
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Grant
|
EXPRESSION OF IMMUNOGLOBULIN GENES
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